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医療専門家向け Hot Flashes and Night Sweats (PDQ®)

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This PDQ cancer information summary for health professionals provides comprehensive, peer-reviewed, evidence-based information about the pathophysiology and treatment of hot flashes and night sweats. It is intended as a resource to inform and assist clinicians who care for cancer patients. It does not provide formal guidelines or recommendations for making health care decisions.

This summary is reviewed regularly and updated as necessary by the PDQ Supportive and Palliative Care Editorial Board, which is editorially independent of the National Cancer Institute (NCI). The summary reflects an independent review of the literature and does not represent a policy statement of NCI or the National Institutes of Health (NIH).

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Overview

Hot flashes and night sweats are common in cancer survivors, particularly women, but they can also occur in men. Pathophysiologic mechanisms are complex. Treatment options are broad-based, including hormonal agents, nonhormonal pharmacotherapies, and diverse integrative medicine modalities.[ 1 ]

Hot flashes occur in approximately two-thirds of postmenopausal women with a history of breast cancer and are associated with night sweats in 44% of these women.[ 2 ][ 3 ] The severity of hot flashes in patients with breast cancer has been associated with sleep difficulty, higher pain severity, and poor psychological functioning.[ 4 ] In premenopausal breast cancer survivors, vasomotor symptoms—including hot flashes and night sweats—have been associated with depression, an effect that may be mediated by sleep disturbance.[ 5 ] For most breast cancer patients and prostate cancer patients, hot flash intensity is moderate to severe. Sweating can be part of the hot flash complex that characterizes the vasomotor instability of menopause. Physiologically, sweating mediates core body temperature by producing transdermal evaporative heat loss.[ 6 ][ 7 ] Hot flashes accompanied by sweating that occur during the sleeping hours are often called night sweats.[ 8 ] Another synonym found in the literature is hot flushes.

Approximately 20% of women without breast cancer seek medical treatment for postmenopausal symptoms, including symptoms related to vasomotor instability.[ 9 ] Vasomotor symptoms resolve spontaneously in most patients in this population, with only 20% of affected women reporting significant hot flashes 4 years after the last menses.[ 9 ] There are no comparable data for women with metastatic breast cancer. Three-quarters of men with locally advanced or metastatic prostate cancer treated with medical or surgical orchiectomy experience hot flashes.[ 10 ]

In this summary, unless otherwise stated, evidence and practice issues as they relate to adults are discussed. The evidence and application to practice related to children may differ significantly from information related to adults. When specific information about the care of children is available, it is summarized under its own heading.

参考文献
  1. Dalal S, Zhukovsky DS: Pathophysiology and management of hot flashes. J Support Oncol 4 (7): 315-20, 325, 2006 Jul-Aug.[PUBMED Abstract]
  2. Couzi RJ, Helzlsouer KJ, Fetting JH: Prevalence of menopausal symptoms among women with a history of breast cancer and attitudes toward estrogen replacement therapy. J Clin Oncol 13 (11): 2737-44, 1995.[PUBMED Abstract]
  3. Carpenter JS, Andrykowski MA, Cordova M, et al.: Hot flashes in postmenopausal women treated for breast carcinoma: prevalence, severity, correlates, management, and relation to quality of life. Cancer 82 (9): 1682-91, 1998.[PUBMED Abstract]
  4. Chang HY, Jotwani AC, Lai YH, et al.: Hot flashes in breast cancer survivors: Frequency, severity and impact. Breast 27: 116-21, 2016.[PUBMED Abstract]
  5. Accortt EE, Bower JE, Stanton AL, et al.: Depression and vasomotor symptoms in young breast cancer survivors: the mediating role of sleep disturbance. Arch Womens Ment Health 18 (3): 565-8, 2015.[PUBMED Abstract]
  6. Boulant JA: Thermoregulation. In: Machowiak PA, ed.: Fever: Basic Mechanisms and Management. New York, NY: Raven Press, 1991, pp 1-22.[PUBMED Abstract]
  7. Dinarello CA, Bunn PA: Fever. Semin Oncol 24 (3): 288-98, 1997.[PUBMED Abstract]
  8. 8 Causes of Night Sweats. New York, NY: WebMD, 2018. Available online. Last accessed July 15, 2019.[PUBMED Abstract]
  9. Johnson SR: Menopause and hormone replacement therapy. Med Clin North Am 82 (2): 297-320, 1998.[PUBMED Abstract]
  10. Charig CR, Rundle JS: Flushing. Long-term side effect of orchiectomy in treatment of prostatic carcinoma. Urology 33 (3): 175-8, 1989.[PUBMED Abstract]
Etiology

Causes of menopausal hot flashes include the occurrence of natural menopause, surgical menopause, or chemical menopause; in the cancer patient, chemical menopause may be caused by cytotoxic chemotherapy, radiation therapy, or androgen treatment. Causes of so-called male menopause include orchiectomy, gonadotropin-releasing hormone use, or estrogen use. Drug-associated causes of hot flashes and night sweats in men and women include the use of tamoxifen, aromatase inhibitors, opioids, tricyclic antidepressants, and steroids. Women who are extensive metabolizers of tamoxifen related to CYP2D6 may have more severe hot flashes than do women who are poor metabolizers;[ 1 ] however, there are conflicting data surrounding this topic.[ 2 ]

参考文献
  1. Lynn Henry N, Rae JM, Li L, et al.: Association between CYP2D6 genotype and tamoxifen-induced hot flashes in a prospective cohort. Breast Cancer Res Treat 117 (3): 571-5, 2009.[PUBMED Abstract]
  2. Jansen LE, Teft WA, Rose RV, et al.: CYP2D6 genotype and endoxifen plasma concentration do not predict hot flash severity during tamoxifen therapy. Breast Cancer Res Treat 171 (3): 701-708, 2018.[PUBMED Abstract]
Primary Interventions

Hormone Replacement Therapy

Estrogen replacement effectively controls hot flashes associated with biologic or treatment-associated postmenopausal states in women. The proposed mechanism of action of estrogen replacement therapy is that it ameliorates hot flashes by raising the core body temperature sweating threshold;[ 1 ][Level of evidence: I] however, many women have relative or absolute contraindications to estrogen replacement. Physicians and breast cancer survivors often think there is an increased risk of breast cancer recurrence or de novo breast malignancy with hormone replacement therapies and defer hormonal management of postmenopausal symptoms. Methodologically strong data evaluating the risk of breast cancer associated with hormone replacement therapy in healthy women have been minimal, despite strong basic science considerations suggesting the possibility of such a risk.[ 2 ]

In May 2002, the Women’s Health Initiative, a large, randomized, placebo-controlled trial of the risks and benefits of estrogen plus progestin in healthy postmenopausal women, was stopped prematurely at a mean follow-up of 5.2 years (±1.3) because of the detection of a 1.26-fold increased breast cancer risk (95% confidence interval [CI], 1.00–1.59) in women receiving hormone replacement therapy. Tumors among women in the hormone replacement therapy group were slightly larger and more advanced than tumors among women in the placebo group, with a substantial and statistically significant rise in the percentage of abnormal mammograms at first annual screening; such a rise might hinder breast cancer diagnosis and account for the later stage at diagnosis.[ 3 ][ 4 ][Level of evidence: I] These results are supported by a population-based case-control study suggesting a 1.7-fold (95% CI, 1.3–2.2) increased risk of breast cancer in women using combined hormone replacement therapy. The risk of invasive lobular carcinoma was increased 2.7-fold (95% CI, 1.7–4.3), the risk of invasive ductal carcinoma was increased 1.5-fold (95% CI, 1.1–2.0), and the risk of estrogen receptor–positive/progesterone receptor–positive breast cancer was increased 2.0-fold (95% CI, 1.5–2.7). The increased risk was highest for invasive lobular tumors and in women who used hormone replacement therapy for longer periods. The risk was not increased with unopposed estrogen therapy.[ 5 ]

The very limited data available do not indicate an increased risk of breast cancer recurrence with single-agent estrogen use in patients with a history of breast cancer.[ 6 ][ 7 ] A series of double-blind placebo-controlled trials suggested that low-dose megestrol acetate is a promising agent for hot flash management in this population.[ 8 ][Level of evidence: I];[ 9 ][Level of evidence: II] Limited data suggest that brief cycles of intramuscular depot medroxyprogesterone acetate also play a role in the management of hot flashes.[ 10 ][Level of evidence: I] The risk associated with progestin use is unknown.[ 2 ]

Examples of hormone-based pharmacologic treatments for vasomotor symptoms are summarized in Table 1.

Table 1. Hormone-Based Treatment of Vasomotor Symptoms
Drug Category Medication Dose Comment Reference
IM = intramuscular; PO = by mouth; qd = every day.
Estrogen Example: 17-beta-estradiol 0.5 mg PO q24h Multiple routes available; consider use of estrogen/progestin combination products for women with intact uteri. [ 11 ]; [ 12 ][Level of evidence: I]
Progestin Megestrol acetate 20 mg PO qd Studied in men and women. [ 8 ][Level of evidence: I]; [ 9 ][Level of evidence: III]
Medroxyprogesterone 400 mg IM x 1   [ 13 ][Level of evidence: I]; [ 14 ][Level of evidence: III]

Other Pharmacologic Interventions

Numerous nonestrogenic, pharmacologic treatment interventions for hot flash management in women with a history of breast cancer and in some men who have undergone androgen deprivation therapy have been evaluated. Options with reported efficacy include androgens, progestational agents, gabapentin, selective serotonin reuptake inhibitors (SSRIs), selective serotonin norepinephrine inhibitors, alpha adrenergic agonists (e.g., methyldopa, clonidine), and beta-blockers. Inferior efficacy, lack of large definitive studies, and potential side effects limit the use of many of these agents.[ 15 ][ 16 ][ 17 ][Level of evidence: I]

Agents that have been found to be helpful in large, randomized, placebo-controlled clinical trials include venlafaxine, paroxetine, citalopram, fluoxetine, gabapentin, pregabalin, and clonidine.[ 15 ][ 16 ][ 17 ] Agents conferring a 55% to 60% reduction in hot flashes are venlafaxine extended release,[ 18 ] paroxetine controlled release [ 19 ][ 20 ][Level of evidence: I] or immediate release,[ 21 ] gabapentin,[ 22 ][ 23 ][ 24 ][ 25 ][Level of evidence: I];[ 26 ][Level of evidence: II] and pregabalin.[ 27 ][Level of evidence: I] Other effective agents resulting in a reduction in hot flashes of approximately 50% include citalopram [ 28 ][Level of evidence: I] and fluoxetine.[ 29 ][Level of evidence: I] Clonidine, transdermal [ 30 ] or oral,[ 31 ][Level of evidence: I] can reduce hot flashes by approximately 40%.

One study compared the efficacy and patient preference of venlafaxine, 75 mg, once daily to gabapentin, 300 mg, 3 times per day for the reduction of hot flashes. Sixty-six women with histories of breast cancer were randomly assigned in an open-label fashion to receive venlafaxine or gabapentin for 4 weeks; after a 2-week washout period, they received the opposite treatment for an additional 4 weeks. Both treatments reduced hot flash scores (severity multiplied by frequency) by approximately 66%. However, significantly more women preferred venlafaxine to gabapentin (68% vs. 32%, respectively).[ 22 ]

A study using citalopram to evaluate hot flashes examined how much of a reduction in hot flashes was needed to have a positive impact on activities of daily living and general health-related quality of life.[ 32 ] The authors reported that hot flashes had to be reduced at least 46% for women to report significant improvements in the degree of bother they experienced in daily activities.

In a randomized study of paroxetine versus placebo in postmenopausal gynecological cancer survivors, paroxetine significantly reduced the severity and frequency of hot flashes and nighttime awakening attributed to vasomotor symptoms, with improvement in sleep duration.[ 20 ][Level of evidence: I]

Agents that have been evaluated in phase II trials but have not shown efficacy include bupropion,[ 33 ] aprepitant,[ 34 ] and desipramine.[ 35 ][Level of evidence: II] Interestingly, these agents do not primarily modulate serotonin. In addition, randomized clinical trials with sertraline have not provided convincing evidence of its efficacy in hot flash management.[ 36 ][ 37 ][ 38 ][Level of evidence: I]

Examples of nonhormonal pharmacologic treatments for vasomotor symptoms are summarized in Table 2.

Table 2. Nonhormonal Treatment of Vasomotor Symptoms
Drug Category Medication Dose Comment Reference
bid = twice a day; CR = controlled release; ER = extended release; GABA = gamma-aminobutyric acid; IR = immediate release; PO = by mouth; qam = every morning; qhs = once daily at bedtime; VMS = vasomotor symptoms.
Selective serotonin reuptake inhibitor Citalopram 10–20 mg PO q24h Mixed efficacy results [ 28 ][Level of evidence: I]
Escitalopram 10–20 mg PO q24h Studied in a non-oncology patient population [ 39 ][ 40 ][Level of evidence: I]
Fluoxetine 20 mg PO q24h   [ 29 ][Level of evidence: I]
Paroxetine IR: 10–20 mg PO q24h Brisdelle branded product for VMS 7.5 mg PO qhs [ 19 ][ 20 ][ 21 ][Level of evidence: I]
CR: 12.5–25 mg PO q24h
Sertraline 50 mg PO q24h Benefit seen over placebo after crossover, but not vs. baseline VMS [ 36 ][Level of evidence: I]
Serotonin/norepinephrine reuptake inhibitor Venlafaxine 37.5–150 mg/d (daily dosing for ER or in 2–3 divided doses for IR for doses >37.5 mg)   [ 11 ]; [ 18 ][ 41 ][ 42 ][Level of evidence: I]
Duloxetine 30 mg qam x 1 wk, then 60 mg qam Equivalent to escitalopram (10 mg qam x 1 week, then 20 mg qam) in reducing hot flash severity and frequency, and depressive symptoms [ 43 ][Level of evidence: I]
Alpha-2 antagonist antidepressant Mirtazapine 7.5–30 mg qhs Small pilot trial; target dose, 15–30 mg [ 44 ][Level of evidence: II]
Anticonvulsant/GABA analog Gabapentin Initial, 300 mg qhs; titrate up to 900 mg/d in divided doses Mixed results depending on comparator group; studied in men and women [ 22 ][ 23 ][ 24 ][ 26 ][Level of evidence: I]
Pregabalin 50 mg qhs, then 50–150 mg PO bid Titrations should be made weekly, to a target dose of 75 mg PO bid [ 11 ]; [ 27 ][Level of evidence: I]
Alpha-2 adrenergic agonist Clonidine 0.1 mg/24 h transdermal; 0.1 mg PO q24h Sudden cessation can result in significant hypertension; no efficacy demonstrated in men with postorchiectomy hot flashes [ 31 ][ 45 ][Level of evidence: I]

If nighttime hot flashes or night sweats are a particular problem without causing much bother during daytime, strategies to simultaneously improve sleep and hot flashes are in order. Limited data exist related to effective treatments that can target both symptoms. One pilot trial evaluated mirtazapine (a tetracyclic antidepressant that mainly affects serotonin) for hot flashes because it is often prescribed for sleep difficulties. Twenty-two women were titrated up to 30 mg per day of mirtazapine at bedtime over a 3-week period; then they could choose 15 mg or 30 mg at bedtime daily for the fourth week. Hot flashes were reduced by approximately 53% in this nonrandomized trial, and women were statistically significantly satisfied with their hot flash control.[ 44 ] However, only 16 of the 22 women stayed on the agent for the entire study period because of excessive grogginess. Therefore, although this agent could be further studied in a larger randomized trial, it would be particularly important to evaluate the risk/benefit ratio.

In the short term, side effects for antidepressant agents in the doses used to treat hot flashes are minimal and primarily include nausea, sedation, dry mouth, and appetite suppression or stimulation. In the long term, the prevalence of decreased sexual function with the use of SSRIs at doses for treating hot flashes is not known. The anticonvulsants gabapentin and pregabalin can cause sedation, dizziness, and difficulty concentrating, while clonidine can cause dry mouth, sedation, constipation, and insomnia.[ 25 ][ 27 ][ 46 ][Level of evidence: I] Patients respond as individuals to both the efficacy and the toxicity of various medications. Therefore, careful assessment and tailored treatment chosen collaboratively by provider and health care consumer are needed.

Data indicate that if a medication does not help an individual, switching to another medication—whether a different antidepressant or gabapentin—may be worthwhile. In a randomized phase III trial (NCCTG-N03C5) of gabapentin alone versus gabapentin in conjunction with an antidepressant in women who had inadequate control of their hot flashes with an antidepressant alone,[ 47 ][Level of evidence: I] gabapentin use resulted in an approximately 50% median reduction in hot flash frequency and score, regardless of whether the antidepressant was continued. In other words, for women who were using antidepressants exclusively for the management of hot flashes that were inadequately controlled, initiation of gabapentin with discontinuation of the antidepressant produced results equal to those obtained with combined therapy, resulting in the need for fewer medications. Similarly, in a pilot study of women receiving inadequate benefit from venlafaxine for hot flash reduction, switching to open-label citalopram, 20 mg per day, resulted in a 50% reduction in hot flash frequency and score.[ 48 ]

Drug Interactions

Many of the SSRIs can inhibit the cytochrome P450 enzymes involved in the metabolism of tamoxifen, which is commonly used in the treatment of breast cancer. When SSRIs are being used, drug-drug interactions are noted. Tamoxifen, used in the management of breast cancer, is metabolized by the cytochrome P450 enzyme system, specifically CYP2D6. Wild-type CYP2D6 metabolizes tamoxifen to an active metabolite, 4-hydroxy-N-desmethyl-tamoxifen, also known as endoxifen. A prospective trial evaluating the effects of the coadministration of tamoxifen and paroxetine, a CYP2D6 inhibitor, on tamoxifen metabolism, found that paroxetine coadministration resulted in decreased concentrations of endoxifen. The magnitude of decrease was greater in women with the wild-type CYP2D6 genotype than in those with a variant genotype (P = .03).[ 49 ][Level of evidence: II]

In a prospective observational study of 80 women initiating adjuvant tamoxifen therapy for newly diagnosed breast cancer, variant CYP2D6 genotypes and concomitant use of SSRI CYP2D6 inhibitors resulted in reduced endoxifen levels. Variant CYP2D6 genotypes do not produce functional CYP2D6 enzymes.[ 50 ][Level of evidence: II] Since this study was published, several researchers have been evaluating the clinical implications of this finding.[ 51 ];[ 52 ][ 53 ][ 54 ][Level of evidence: II] One study followed more than 1,300 women for a median of 6.3 years and concluded that women who were poor metabolizers or heterozygous extensive/intermediate metabolizers (hence, less CYP2D6 activity) had higher rates of recurrence, worse event-free survival, and worse disease-free survival than did women who were extensive metabolizers.[ 53 ] Similarly, a retrospective cohort study of more than 2,400 women in Ontario who were being treated with tamoxifen and had overlapping treatment with an SSRI has been completed. Authors concluded that women who concomitantly used paroxetine and tamoxifen had an increased risk of death that was proportionate to the amount of time they used these agents together.[ 54 ][Level of evidence: II]

The clinical implications of these changes and of other CYP2D6 genotypes [ 55 ] have not yet been elucidated, but the pharmacokinetic interaction between tamoxifen and the newer antidepressants used to treat hot flashes merits further study.[ 56 ] Likewise, the risk of soy phytoestrogen use on breast cancer recurrence and/or progression has not yet been clarified. Soy phytoestrogens are weak estrogens found in plant foods. In vitro models suggest that these compounds have a biphasic effect on mammary cell proliferation that is dependent on intracellular concentrations of phytoestrogen and estradiol.[ 57 ]

Information Specific to Men

Data regarding the pathophysiology and management of hot flashes in men with prostate cancer are scant. The rate of hot flashes in men receiving androgen deprivation therapy is approximately 75%.[ 58 ] The limited data that exist suggest that hot flashes in men are related to changes in sex hormone levels that cause instability in the hypothalamic thermoregulatory center analogous to the proposed mechanism of hot flashes that occur in women. As in women with breast cancer, hot flashes impair the quality of life for men with prostate cancer who are receiving androgen deprivation therapy. The vasodilatory neuropeptide, calcitonin gene–related peptide, may be instrumental in the genesis of hot flashes.[ 58 ]

In a prespecified secondary analysis of a prostate cancer clinical trial, 93% of men receiving 12 months of androgen deprivation therapy experienced hot flashes. The hot flashes occurred at castrate levels of testosterone, and cessation of hot flashes preceded full recovery of testosterone in most men, with 99% of men reporting resolution of hot flashes.[ 59 ][Level of evidence: I]

Cognitive behavioral therapy (CBT) has been studied for the treatment of hot flashes in men undergoing androgen deprivation therapy for prostate cancer.[ 60 ][Level of evidence: I] Patients were randomly assigned to a guided self-help CBT regimen that included a booklet and CD with relaxation and breathing exercises, or to treatment as usual. At 6 weeks, those assigned to CBT experienced a statistically significant 40% reduction in hot flash/night sweat symptoms versus a 12% reduction in patients who received treatment as usual. Symptom reduction continued but was not statistically significant at 32 weeks. Adherence to CBT was good, with 88% reading all or more than half of the booklet and 79% using the relaxation CD.

With the exception of clonidine, the agents mentioned previously (refer to the Other Pharmacologic Interventions section of this summary) that have been found to be effective in the treatment of hot flashes in women have shown similar rates of efficacy when studied in men. Treatment modalities have included estrogens, progesterone, SSRIs, and gabapentin as options for men.[ 61 ]

One large, multisite study from France [ 62 ] randomly assigned men who were taking leuprorelin for prostate cancer to receive venlafaxine, 75 mg; cyproterone acetate (an antiandrogen), 100 mg; or medroxyprogesterone acetate, 20 mg, when they reported at least 14 hot flashes per week. All three treatments significantly reduced hot flashes, with cyproterone resulting in a 100% median reduction, medroxyprogesterone resulting in a 97% reduction, and venlafaxine resulting in a 57% reduction at 8 weeks. More adverse events were reported with cyproterone acetate, including one serious adverse event (dyspnea) attributable to the drug. Venlafaxine was not associated with any serious adverse events and overall had a 20% adverse event rate attributable to the drug. Medroxyprogesterone was the most well-tolerated drug, with an adverse event rate of 12%, but with one serious event, urticaria. The most frequent side effects for all agents were related to gastrointestinal issues: nausea, constipation, diarrhea, and abdominal pain.[ 62 ]

On the basis of its efficacy in women, the combination of venlafaxine and soy was studied in hot flash reduction in androgen-deprived men.[ 63 ][Level of evidence: I] Patients were randomly assigned to receive venlafaxine with soy protein, venlafaxine with milk protein placebo, soy protein with placebo, or dual placebos during a 12-week period. The number and severity of hot flashes fell for all arms during the study period, but there was no significant difference between arms. The authors concluded that neither agent should be used to treat hot flashes in men; that there is a significant placebo effect in the study of hot flash treatment; and that agents demonstrating success for hot flashes in women may not be successful in men.

A small, multicenter, retrospective review evaluated the use of two doses of intramuscular medroxyprogesterone acetate (400 mg and 150 mg) as a single dose to treat and prevent hot flashes associated with luteinizing hormone-releasing hormone agonist therapy for prostate cancer.[ 14 ][Level of evidence: III] Of the 48 men studied, 91% experienced symptomatic improvement in hot flashes, and 46% experienced complete resolution of hot flashes. The trial was not powered to detect a difference between the two doses; however, the authors concluded that they would now use the 400-mg dose.

Pilot studies of the efficacy of the SSRIs paroxetine and fluvoxamine suggest that these drugs decrease the frequency and severity of hot flashes in men with prostate cancer.[ 64 ][ 65 ] As in women with hormonally sensitive tumors, there are concerns about the effects of hormone use on the outcome of prostate cancer, in addition to other well-described side effects.[ 58 ]

Cognitive and Behavioral Methods

Comprehensive nonpharmacologic interventions have been developed and evaluated for their ability to reduce hot flashes, night sweats, and the perception of burden or problems related to hot flashes and night sweats. These interventions have typically included the following:[ 66 ][ 67 ][ 68 ][ 69 ]

Behavioral interventions as a primary or adjunctive modality may also play a role in hot flash management. Core body temperature has been shown to increase before a hot flash;[ 70 ] therefore, interventions that control body temperature could improve hot flash management. Some methods of controlling body temperature include the use of loose-fitting cotton clothing and the use of fans and open windows to keep air circulating. On the basis of the theory that serotonin may be involved as a central hot flash trigger, behavioral interventions such as stress management may modulate serotonin, causing a decrease in hot flashes.

Relaxation training and paced breathing were initially found to decrease hot flash intensity by as much as 40% to 50% in controlled pilot trials;[ 71 ][ 72 ] however, randomized trials with control arms using a different pace of breathing have not demonstrated significant benefit for paced-breathing interventions.[ 73 ][ 74 ]

Three large studies [ 67 ][ 68 ][ 69 ] with similar interventions have been completed using no treatment, usual care, or wait-list control comparison groups. While all of the studies demonstrated significant reductions in problem ratings or bother ratings related to hot flashes and night sweats, none showed actual reductions in hot flash frequency. Only one of the three studies demonstrated some significant improvements in night sweats at some data points.[ 68 ] Similar results were seen in a large trial of Internet-based CBT with and without therapist support.[ 75 ][Level of evidence: I] Cognitive behavioral interventions may be an important addition to pharmacological treatment to improve a patient’s overall experience with symptoms related to hot flashes. However, data have not supported the sole use of CBT for reducing hot flashes.

Medical hypnosis is a newer intervention for hot flashes that has been shown to be helpful. In medical hypnosis, the provider facilitates a deep relaxation and trance state and, with the patient in that state, gives suggestions to the subconscious that would mitigate the symptom or problem being addressed. For hot flashes, medical hypnosis uses cooling suggestions and stress reduction to prevent rises in core body temperature and to decrease sympathetic activation. On the basis of strong pilot data, a randomized controlled trial of 187 postmenopausal women used an attention-control comparison and demonstrated significantly greater reductions in hot flashes in the hypnosis group than in the control group. The hypnosis intervention was 5 weeks long. At week 6, hot flash frequency was reduced in the hypnosis group by 64%, compared with a 9% reduction in the control group. At week 12, the reduction in the hypnosis group was 75%, compared with a 17% reduction in the control group.[ 76 ] Cancer survivors were not included in this study, but previous research has not demonstrated that interventions have a differential effect on hot flashes on the basis of breast cancer history.

Future research on hot flash management may be aided by the development of psychometrically sound assessment tools such as the Hot Flash Related Daily Interference Scale, which evaluates the impact of hot flashes on a wide variety of daily activities.[ 77 ]

Integrative Approaches

Herbs/dietary supplements

Numerous herbs and dietary supplements are popularly used for hot flash reduction. Several of these substances have not been well studied in rigorous clinical trials. Furthermore, the biologic activity of various over-the-counter supplements has yet to be determined and is far from standardized. Some of the more well-studied agents include soy phytoestrogen, black cohosh, and vitamin E.

Vitamin E, 400 IU twice a day, appears to confer a modest reduction in hot flashes that is only slightly better than that seen with placebo. The reduction in hot flashes is roughly 35% to 40%.[ 78 ][ 79 ][Level of evidence: I]

Soy has been a dietary supplement of interest for decreasing menopausal symptoms and breast cancer for some time. The interest comes primarily from association studies of a high-soy diet and decreased breast cancer/menopausal symptoms in Asia. Soy is an isoflavone, which is part of a much larger class of plant compounds called flavonoids. Three types of isoflavones are found in soy products:

Isoflavones are often referred to as phytoestrogens or plant-based estrogens because they have been shown, in cell line and animal studies, to have the ability to bind with the estrogen receptor.[ 80 ]

There is confusion about the safety of these plant-based estrogens because these agents can have properties that can cause estrogen-like effects in some cells, causing them to proliferate (divide and grow); while in other cells, isoflavones can stop or block estrogen effects, causing unwanted cells to not grow or even die. There is continuing debate about the following questions:[ 81 ]

Definitive answers to these questions are not known, but phytoestrogens continue to be investigated for chemopreventive properties. On the other hand, soy has been well studied in numerous randomized, placebo-controlled trials for its effects on reducing hot flashes.[ 82 ][ 83 ][ 84 ][ 85 ][ 86 ][Level of evidence: I] Most of those trials show that soy is no better than a placebo in reducing hot flashes.[ 87 ][Level of evidence: I];[ 88 ] There are no compelling data that would inspire the use of soy for hot flash management.

Similarly, trials of black cohosh that have been well designed with a randomized, placebo-controlled arm have also found that black cohosh is no better than a placebo in reducing hot flashes.[ 86 ][ 89 ][ 90 ][Level of evidence: I] Furthermore, a meta-analysis that included 14 randomized controlled trials of black cohosh concluded there is a lack of evidence to support its use in the treatment of hot flashes.[ 91 ]

Black cohosh used to be thought of as having estrogenic properties, but it is now known that black cohosh acts on serotonin receptors, as discussed at the 2004 Workshop on the Safety of Black Cohosh in Clinical Studies. One study evaluated black cohosh, red clover, estrogen and progesterone, and placebo in a randomized, double-blind trial.[ 92 ][Level of evidence: I] Each treatment arm was small (n = 22); however, over 12 months, hot flashes were reduced 34% by black cohosh, 57% by red clover, 63% by placebo, and 94% by hormone therapy. Of note, adherence rates were approximately 89% across the four groups during this long-term study. At 12 months, physiologic markers such as endometrial thickness, estradiol, estrone, follicle-stimulating hormone, sex hormone–binding globulin, and liver function were not statistically different for those on either red clover or black cohosh, compared with those on placebo. However, because these groups were small, the power for this secondary analysis was not reported, and it was likely underpowered to detect important differences.

Flaxseed is a plant that is part of the genus Linum, native to the area around the eastern Mediterranean and India. Flaxseed is a rich source of lignans and omega-3 fatty acids. Lignans found in flaxseed are called secoisolariciresinol diglucoside and alpha-linolenic acid. Flaxseed is also a source of fiber. Lignans are a type of phytoestrogen (plant estrogen) that, like soy, is thought to have estrogen agonist-antagonist effects as well as antioxidant properties. Lignans are converted by colonic bacteria to enterodiol and enterolactone, which are metabolites believed to have important physiological properties such as decreasing cell proliferation and inhibiting aromatase, 5-alpha reductase, and 17-beta hydroxysteroid activity. Cell line studies have shown properties of aromatase inhibition with enterolactone but less so with enterodiol.[ 93 ] It is thought that these properties can reduce the risk of hormone-sensitive cancers.[ 94 ][ 95 ][ 96 ] In addition, studies have shown that flaxseed can reduce estrogen levels through excretion in the urine.[ 97 ][ 98 ]

On the basis of preliminary data testing flaxseed for its effect on hot flashes and related endpoints,[ 99 ][ 100 ][Level of evidence: I] an open-label pilot study was conducted to evaluate 40 g of flaxseed in decreasing hot flashes. This study of 30 women showed a 57% reduction in hot flash scores and a 50% reduction in hot flash frequency over a 6-week period.[ 101 ] However, a follow-up phase III, randomized, controlled trial conducted by the North Central Cancer Treatment Group with 188 women failed to show any benefit of 410 mg of lignans in a flaxseed bar over placebo.[ 102 ][Level of evidence: I]

Similarly, on the basis of two pilot studies suggesting that magnesium oxide supplementation significantly reduced hot flashes, a double-blind, randomized, placebo-controlled trial of magnesium oxide, 800 or 1,200 mg daily, versus placebo was conducted in postmenopausal women with a history of breast cancer and symptomatic hot flashes.[ 103 ][Level of evidence: I] No benefit was observed for magnesium oxide.

Many plants and natural products are touted as wonderful remedies for hot flashes. Some of these products are plant phytoestrogens, and some have unknown properties. The agents include dong quai, milk thistle, red clover, licorice, and chaste tree berry. There is incomplete understanding of the biology of these agents and whether taking them would impact breast cancer risk or recurrence in a negative or positive way. Data suggest that these plants have different effects, dependent not only on the dose used but also on a woman's hormone environment when she takes them. Little is known about these agents, and caution with respect to taking them—if a woman is to avoid estrogen supplementation—is needed.[ 104 ][ 105 ][ 106 ][ 107 ]

Acupuncture

Pilot and randomized sham trials have evaluated the use of acupuncture to treat hot flashes.[ 108 ][ 109 ][ 110 ][ 111 ][ 112 ][Level of evidence: I] Research in acupuncture is difficult to conduct, owing to the lack of novel methodology—specifically, the conundrum of what serves as an adequate control arm. In addition, the philosophy surrounding acupuncture practice is quite individualized, in that two women experiencing hot flashes would not necessarily receive the same treatment. It would be important to study acupuncture utilizing relevant clinical procedures; so far, acceptable research methods to accomplish this are lacking. Therefore, the data with respect to the effect of acupuncture on hot flashes are quite mixed. However, a 2016 meta-analysis of 12 trials studying acupuncture for the treatment of hot flashes in patients with breast cancer showed limited or no effects for acupuncture.[ 113 ] Included trials ranged in size from 10 to 84 patients, with 5 to 16 treatment sessions and 1 to 24 months of follow-up. Comparator arms included hormone therapy, relaxation techniques, sham acupuncture, and antidepressants. The authors concluded that acupuncture failed to demonstrate a significant effect on the frequency of hot flashes in a population of breast cancer patients.

In contrast, a randomized controlled trial that was not included in the 2016 meta-analysis showed a statistically significant reduction in hot flash score with acupuncture.[ 114 ][Level of evidence: I] The trial randomly assigned women to ten acupuncture sessions plus enhanced self-care versus enhanced self-care alone. Women were included if they had breast cancer; at least moderate-level hot flashes, defined as six or more hot flashes a day; and/or a score of 15 or higher on the Greene Climacteric Scale. Random assignment to acupuncture resulted in fewer hot flashes and higher quality of life. The reduction in hot flash score was maintained through the 3- and 6-month follow-up visits.

In a randomized controlled trial, breast cancer survivors with hot flashes (120 women) were randomly assigned to receive electroacupuncture (using a transcutaneous electrical nerve stimulation unit to induce a current between two acupuncture points) or gabapentin, 900 mg daily, with sham electroacupuncture (needles that did not penetrate the skin and without electricity) and placebo capsules as controls.[ 24 ] Electroacupuncture produced the greatest reduction in hot flash symptoms, followed by sham acupuncture, gabapentin, and placebo capsules. In a separately published, prespecified secondary analysis of sleep outcomes in women assigned to the active treatment arms, electroacupuncture was comparable to gabapentin for improving sleep quality; significant associations were seen between reduction in hot flash severity/frequency and improved sleep latency and sleep quality in the full sample.[ 115 ]

Refer to the Vasomotor symptoms section in the PDQ summary on Acupuncture for more information.

Current Clinical Trials

Use our advanced clinical trial search to find NCI-supported cancer clinical trials that are now enrolling patients. The search can be narrowed by location of the trial, type of treatment, name of the drug, and other criteria. General information about clinical trials is also available.

参考文献
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  99. Lemay A, Dodin S, Kadri N, et al.: Flaxseed dietary supplement versus hormone replacement therapy in hypercholesterolemic menopausal women. Obstet Gynecol 100 (3): 495-504, 2002.[PUBMED Abstract]
  100. Lewis JE, Nickell LA, Thompson LU, et al.: A randomized controlled trial of the effect of dietary soy and flaxseed muffins on quality of life and hot flashes during menopause. Menopause 13 (4): 631-42, 2006 Jul-Aug.[PUBMED Abstract]
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  102. Pruthi S, Qin R, Terstreip SA, et al.: A phase III, randomized, placebo-controlled, double-blind trial of flaxseed for the treatment of hot flashes: North Central Cancer Treatment Group N08C7. Menopause 19 (1): 48-53, 2012.[PUBMED Abstract]
  103. Park H, Qin R, Smith TJ, et al.: North Central Cancer Treatment Group N10C2 (Alliance): a double-blind placebo-controlled study of magnesium supplements to reduce menopausal hot flashes. Menopause 22 (6): 627-32, 2015.[PUBMED Abstract]
  104. Liu J, Burdette JE, Xu H, et al.: Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms. J Agric Food Chem 49 (5): 2472-9, 2001.[PUBMED Abstract]
  105. Tamir S, Eizenberg M, Somjen D, et al.: Estrogenic and antiproliferative properties of glabridin from licorice in human breast cancer cells. Cancer Res 60 (20): 5704-9, 2000.[PUBMED Abstract]
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  107. Rotem C, Kaplan B: Phyto-Female Complex for the relief of hot flushes, night sweats and quality of sleep: randomized, controlled, double-blind pilot study. Gynecol Endocrinol 23 (2): 117-22, 2007.[PUBMED Abstract]
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  109. Hervik J, Mjåland O: Acupuncture for the treatment of hot flashes in breast cancer patients, a randomized, controlled trial. Breast Cancer Res Treat 116 (2): 311-6, 2009.[PUBMED Abstract]
  110. Vincent A, Barton DL, Mandrekar JN, et al.: Acupuncture for hot flashes: a randomized, sham-controlled clinical study. Menopause 14 (1): 45-52, 2007 Jan-Feb.[PUBMED Abstract]
  111. Borud EK, Alraek T, White A, et al.: The effect of TCM acupuncture on hot flushes among menopausal women (ACUFLASH) study: a study protocol of an ongoing multi-centre randomised controlled clinical trial. BMC Complement Altern Med 7: 6, 2007.[PUBMED Abstract]
  112. Liljegren A, Gunnarsson P, Landgren BM, et al.: Reducing vasomotor symptoms with acupuncture in breast cancer patients treated with adjuvant tamoxifen: a randomized controlled trial. Breast Cancer Res Treat 135 (3): 791-8, 2012.[PUBMED Abstract]
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Changes to This Summary (09/17/2019)

The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.

This summary was comprehensively reviewed and extensively revised.

This summary is written and maintained by the PDQ Supportive and Palliative Care Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ® - NCI's Comprehensive Cancer Database pages.

About This PDQ Summary

Purpose of This Summary

This PDQ cancer information summary for health professionals provides comprehensive, peer-reviewed, evidence-based information about the pathophysiology and treatment of hot flashes and night sweats. It is intended as a resource to inform and assist clinicians who care for cancer patients. It does not provide formal guidelines or recommendations for making health care decisions.

Reviewers and Updates

This summary is reviewed regularly and updated as necessary by the PDQ Supportive and Palliative Care Editorial Board, which is editorially independent of the National Cancer Institute (NCI). The summary reflects an independent review of the literature and does not represent a policy statement of NCI or the National Institutes of Health (NIH).

Board members review recently published articles each month to determine whether an article should:

Changes to the summaries are made through a consensus process in which Board members evaluate the strength of the evidence in the published articles and determine how the article should be included in the summary.

Any comments or questions about the summary content should be submitted to Cancer.gov through the NCI website's Email Us. Do not contact the individual Board Members with questions or comments about the summaries. Board members will not respond to individual inquiries.

Levels of Evidence

Some of the reference citations in this summary are accompanied by a level-of-evidence designation. These designations are intended to help readers assess the strength of the evidence supporting the use of specific interventions or approaches. The PDQ Supportive and Palliative Care Editorial Board uses a formal evidence ranking system in developing its level-of-evidence designations.

Permission to Use This Summary

PDQ is a registered trademark. Although the content of PDQ documents can be used freely as text, it cannot be identified as an NCI PDQ cancer information summary unless it is presented in its entirety and is regularly updated. However, an author would be permitted to write a sentence such as “NCI’s PDQ cancer information summary about breast cancer prevention states the risks succinctly: [include excerpt from the summary].”

The preferred citation for this PDQ summary is:

PDQ® Supportive and Palliative Care Editorial Board. PDQ Hot Flashes and Night Sweats. Bethesda, MD: National Cancer Institute. Updated <MM/DD/YYYY>. Available at: https://www.cancer.gov/about-cancer/treatment/side-effects/hot-flashes-hp-pdq. Accessed <MM/DD/YYYY>. [PMID: 26389188]

Images in this summary are used with permission of the author(s), artist, and/or publisher for use within the PDQ summaries only. Permission to use images outside the context of PDQ information must be obtained from the owner(s) and cannot be granted by the National Cancer Institute. Information about using the illustrations in this summary, along with many other cancer-related images, is available in Visuals Online, a collection of over 2,000 scientific images.

Disclaimer

The information in these summaries should not be used as a basis for insurance reimbursement determinations. More information on insurance coverage is available on Cancer.gov on the Managing Cancer Care page.

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